The KAPS (Knowledge Assessment of Pharmaceutical Sciences) exam tests your knowledge and understanding of pharmaceutical sciences. Passing it confirms that you know enough to practise safely and effectively in an Australian setting.

This guide to the KAPS exam outlines the subject areas we assess, and will help you to prepare for the exam. You'll need to assess your own knowledge level, then evaluate that knowledge as much you can against the exam material.

On this page:

Preparing for the exam

Exam format

The KAPS exam consists of 200 questions delivered over two 2-hour sessions (a total of 4 hours of assessment) with a 60-minute scheduled break between papers.

Before starting the exam, you are given 15 minutes to complete a tutorial designed to familiarise yourself with the exam software. You're given 5 minutes at the end of the exam to complete a survey.

All questions are multiple-choice questions with one correct answer out of four options.

KAPS is a closed-book exam. This means you cannot bring any printed or handwritten reference materials into the exam with you.

We base our exams on the latest information, which you can find in relevant:

  • journals
  • publications
  • textbooks

It's up to you to find this information. We do not endorse any external reference sources.
 

Style conventions

Medicine and ingredient names will be presented as per the Therapeutic Goods Administration (TGA) list of approved names.

Values will be presented will be in SI (metric) units.

Units for quantities of drugs and directions for medications follow the approved abbreviations from the Recommendations for terminology, abbreviations and symbols used in medicines documentation.

Determiners are bold and capitalised to draw your attention to the kind of response expected. e.g. CORRECT, MOST, LEAST, NOT.

Distribution per content area

Content area

Approximate distribution per content area

Paper 1

Pharmaceutical Chemistry

30%

Physiology and Pharmacology

70%

Paper 2

Pharmaceutic

30%

Therapeutics

70%

Exam scoring

You must complete all questions in the paper or papers you sit.

To pass the exam, you need a mark of at least 50% in all subsections of the exam.

Paper 1

Pharmaceutical chemistry 50%

Pharmacology and physiology 50%

Paper 2

Pharmaceutics 50%

Therapeutics 50%

You need an overall mark of at least 50%.

You will receive a results certificate indicating your outcome. We'll email you or your agent when your results are available. Expect this to be around 2 weeks after you sit the exam.

Content areas for the KAPS exam

The KAPS exam consists of 2 papers:

  • Paper 1: Pharmaceutical chemistry, pharmacology and physiology
  • Paper 2: Pharmaceutics and therapeutics

Paper 1: Pharmaceutical chemistry, pharmacology and physiology

Pharmaceutical chemistry

You'll need to show you understand and have suitable knowledge in the following content areas:

Paper 1

Content assessed

Indicative elements

1

Organic chemistry

  • Nomenclature
  • Drug class recognition
  • Reaction types
  • Functional group reactivity
  • Drug stability
  • Acid-base reactions

2

Stereochemistry

  • Nomenclature
  • Optical activity
  • Geometric isomerism
  • Conformation

3

Physical and inorganic chemistry

  • Kinetics
  • Acid-base reactions
  • Phase equilibria

4

Analytical chemistry

  • Spectroscopy
  • Redox reactions
  • Assay techniques
  • Diagnostic agents

5

Biochemistry

  • Nomenclature
  • Structures
  • Biochemical classes
  • Thermodynamics
  • Biochemical pathways

6

Structure-activity relationships

  • Relationship between a chemical or 3D structure and its biological activity

7

Medicinal chemistry

  • Structure-activity relationships
  • Drug presentation and delivery
  • Drug formulation and stability
  • Drug metabolism
  • Mechanism of drug action
  • Modern drug development
  • Absorption, distribution and elimination of drugs

8

Drug metabolism

  • Breakdown and conversion of medicines through regularly occurring bodily process, leading to active ingredients and by-products of the original medicine

Pharmacology and physiology

You'll need to show you understand and have suitable knowledge in the following content areas:

Paper 1

Content assessed

Indicative elements

1

Biochemical pharmacology

  • Principles of drug action
  • Drug interactions
  • Receptor pharmacology
  • Autonomic transmission
  • Endocrine pharmacology
  • Cardiovascular pharmacology
  • Anti-inflammatory agents and analgesics
  • Antibiotics
  • Diuretics
  • Local and general anaesthetics
  • Vitamins
  • Drugs affecting nutritional and metabolic function
  • Drugs affecting the central nervous system

2

Systemic pharmacology

  • The mechanism of drug action as it relates to specific organs and disease states

3

Chemotherapy

  • Antibacterial drugs
  • Antiviral drugs
  • Antifungal drugs
  • Antiprotozoal drugs
  • Anthelmintic drugs
  • Anticancer drugs

4

Toxicology

  • Common side effects
  • Signs of toxicity
  • Mechanism of toxicity

5

Pathophysiology

  • Alteration of physiological processes by drugs or disease states

6

General physiology

  • Normal bodily functions including but not limited to the central nervous, digestive, cardiovascular, lymphatic, nervous, respiratory, urinary, endocrine and reproductive systems and their integration
  • Blood and other body fluids

Paper 2: Pharmaceutics and therapeutics

Pharmaceutics

You'll need to show you understand and have suitable knowledge in the following content areas:

Paper 2

Content assessed

Indicative elements

1

Physical pharmacy

  • Solvents
  • Types of preparation
  • Solutions
  • Suspensions
  • Emulsions

2

Biopharmaceutics

  • Dissolution
  • Drug absorption
  • Bioavailability and bioequivalence
  • Drug interactions with a biopharmaceutical basis

3

Pharmacokinetics and pharmacodynamics

  • Biological half-life
  • Elimination rate constants
  • Apparent volume of distribution
  • Clearance
  • Steady state considerations
  • Drug protein binding
  • Drug metabolism
  • Drug interactions
  • Pharmacogenetics
  • Relevant calculations

4

Pharmaceutical microbiology

  • Preservation
  • Antimicrobial agents
  • Sterilisation technology

5

Formulation

  • Formulation of drugs for various routes of administration
  • Parenteral dose forms
  • Controlled release preparations
  • Evaluation of particular dose forms

6

Dose forms, including extemporaneous preparation

  • Drug products
  • Constituent drug substances
  • Combination compounded products for use via various routes of administration

Therapeutics

You'll need to show you understand and have suitable knowledge in the following content areas:

Paper 2

Content assessed

Indicative elements

1

Calculations

  • Dilutions
  • Percentages
  • Densities
  • Sensitivity of balance
  • Proportions
  • Isotonicity
  • Milliequivalents and milliosmoles
  • Buffers
  • Dose calculations from body weight or surface area
  • Stability

2

Posology and dose determinations

  • Appropriate dosages of common medications
  • Dosage regimens of common medications

3

Medicine choice

  • Demonstrating an understanding of the clinical processes used for choosing the most appropriate drug for the presenting patient and their condition

4

Surgical dressings, applications and associated drug delivery systems

  • Drug choices for surgical dressings
  • The use of and choices for surgical dressings

5

Adverse reactions to drugs

  • Adverse reactions for drugs
  • Relevant patient counselling and advice

6

Drug interactions

  • Drug interactions
  • Relevant patient counselling and advice

7

Drug information

  • Using information sources to find drug and health information relevant to conditions and disease states

8

Managing minor ailments

  • Non-prescription prescribing
  • Diagnosing minor illness
  • Rational over-the-counter product selection
  • Over-the-counter drug information

KAPS exam paper samples

To help you sit the KAPS exam, we provide 2 official sample papers:

These each contain questions to help you practise. These questions are no longer used, but they'll help you understand:

  • the types of content covered in each paper of the exam
  • how questions are presented

If you want to practise the sample papers under exam conditions, you'll need to answer all 100 questions in each paper in 2 hours.

The real KAPS exam is delivered online at an approved test centre. Our exam provider, Pearson Vue, provides an online sample test to experience the exam software before your exam day.

Contact the exams team

We are happy to assist you further with any questions you may have. Email us at exams@pharmacycouncil.org.au

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